1H-Isoindol-1-one, 2,3-dihydro-7-iodo-
7-Iodoisoindolinone
CAS: 866766-96-3
Molecular Formula: C8H6INO
1H-Isoindol-1-one, 2,3-dihydro-7-iodo- - Names and Identifiers
1H-Isoindol-1-one, 2,3-dihydro-7-iodo- - Physico-chemical Properties
| Molecular Formula | C8H6INO |
| Molar Mass | 259.04 |
| Density | 1.945±0.06 g/cm3(Predicted) |
| Boling Point | 467.1±45.0 °C(Predicted) |
| Flash Point | 236.283 °C |
| pKa | 13.31±0.20(Predicted) |
| Storage Condition | 2-8°C |
1H-Isoindol-1-one, 2,3-dihydro-7-iodo- - Introduction
7-lodoisoindolinone (7-lodoisoindolinone) is an organic compound whose chemical formula is C8H6INO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 7-lodoisoindolinone is a white crystalline solid.
-Melting point: Its melting point range is about 142-145°C.
-Solubility: It is easy to dissolve in organic solvents.
Use:
-Chemical synthesis: 7-Iodoisoindolinone can be used in organic synthesis reactions, such as olefin cyclization reactions, oxidation reactions, etc.
-Drug research and development: It can be used as an intermediate of drug molecules and has certain applications in the field of drug research and development.
Preparation Method:
7-Iodoisoindolinone can be prepared by the following steps:
1. The indolyl boronic ester is reacted with 2,3-dichloropyridine in the presence of a base to obtain 2,3-dichloro-7-indolyl-pyrimidine.
2. Reaction of 2,3-dichloro -7-indolyl-pyrimidine with sodium iodide in acetone to give 7-iodo -2,3-dichloro-indole.
3.7-iodo -2,3-dichloro-indole is reacted with sodium sulfite in the presence of sodium hydroxide to obtain 7-iodo -2,3-dihydro-indole -1-one.
4. Finally, 7-Iodoisoindolinone was obtained by purifying 7-Iodoisoindolinone.
Safety Information:
- 7-Iodoisoindolinone lacks toxicity data or safety data, so appropriate safety measures and personal protective equipment should be taken during handling and use.
-For possible inhalation, ingestion and exposure, you must ensure that appropriate ventilation systems and protective equipment are used.
-Should be stored in a dry, dark and well-ventilated place, away from fire and oxidizing agents.
Nature:
-Appearance: 7-lodoisoindolinone is a white crystalline solid.
-Melting point: Its melting point range is about 142-145°C.
-Solubility: It is easy to dissolve in organic solvents.
Use:
-Chemical synthesis: 7-Iodoisoindolinone can be used in organic synthesis reactions, such as olefin cyclization reactions, oxidation reactions, etc.
-Drug research and development: It can be used as an intermediate of drug molecules and has certain applications in the field of drug research and development.
Preparation Method:
7-Iodoisoindolinone can be prepared by the following steps:
1. The indolyl boronic ester is reacted with 2,3-dichloropyridine in the presence of a base to obtain 2,3-dichloro-7-indolyl-pyrimidine.
2. Reaction of 2,3-dichloro -7-indolyl-pyrimidine with sodium iodide in acetone to give 7-iodo -2,3-dichloro-indole.
3.7-iodo -2,3-dichloro-indole is reacted with sodium sulfite in the presence of sodium hydroxide to obtain 7-iodo -2,3-dihydro-indole -1-one.
4. Finally, 7-Iodoisoindolinone was obtained by purifying 7-Iodoisoindolinone.
Safety Information:
- 7-Iodoisoindolinone lacks toxicity data or safety data, so appropriate safety measures and personal protective equipment should be taken during handling and use.
-For possible inhalation, ingestion and exposure, you must ensure that appropriate ventilation systems and protective equipment are used.
-Should be stored in a dry, dark and well-ventilated place, away from fire and oxidizing agents.
Last Update：2024-04-09 21:00:56
